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533 Functionally aged astrocytes retain their receptors and capacity of generating Ca 2+ signalling in response to neurochemical stimulation

This reduced binding affinity may be attributed to a subtle mismatch between part of the suramin molecule and the MARV polymerase binding pocket, or to the absence of the other half of the suramin molecule in the EBOV polymerase structure (PDB: 7YET), which might hinder effective binding to the MARV polymerase

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Supports the use of stabilizing lipids, polymer coatings, double liposomes, and other methods to improve oral liposome stability and absorption