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Drug resistance mechanisms beyond DPP9-NRF2 (255) and AIM2-FOXO3a (258) are also underexploredwhether epigenetic modifications (e.g., DNA methylation of ACSL4), post-translational regulation (e.g., GPX4 ubiquitination), or metabolic rewiring (e.g., alternative antioxidant pathways) drives acquired resistance to ferroptosis inducers requires investigation

High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease

Renal failure is rare in WD, but a hepato-renal syndrome may occur in cases of acute liver failure

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