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doi: 10.1021/ja5131726 21 BurtscherJ.SyedM

By contrast with the rat, the mouse exhibits high constitutive levels of GST activity towards AFB 1 -8,9-epoxide and alpha-class GST in Swiss-Webster mice possess high activity towards AFB 1 -8,9-epoxide and can protect against DNA-binding by AFB 1 metabolites

Notably, the glutamic acid portion of GSH forms a salt bridge with N259, exhibiting a binding energy of 10.9 kcal/mol, which undoubtedly stabilizes this binding mode

Findings suggest it modulates extracellular matrix remodeling and fibrosis, in part through transforming growth factor-beta (TGF-?) signaling pathways [7]

Disclosures: Leidy Estefania Zapata-Pavas: Nothing to Disclose, Marina Serrano-Macia: Nothing to Disclose, Miguel ngel Merlos Rodrigo: Nothing to Disclose, Patricia Pea-SanFelix: Nothing to Disclose, Cludia Gil-Pitarch: Nothing to Disclose, Naroa Goikoetxea-Usandizaga: Nothing to Disclose, Hana Michalkova: Nothing to Disclose, Zbynek Heger: Nothing to Disclose, lvaro del Ro-lvarez: Nothing to Disclose, Laura Royo: Nothing to Disclose, Claudia M