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Immunophenotyping myelodysplastic neoplasms: The role of flow cytometry in the molecular classification era

10.1021/acs.molpharmaceut.8b00921 242

Furthermore, multiple studies have demonstrated that collagen peptides can inhibit the expression of pro-inflammatory factors, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), IL-6, IL-8, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), in fibroblasts and keratinocytes, thereby mitigating inflammatory responses [32, 33]

Relevant to the connection between oncogenic STAT3 and aberrant lipid metabolism, it has been shown that STAT3-activated CD36 contributes to fatty acid uptake in chronic lymphocytic leukemia cells (106), which supports a critical role of STAT3 in the regulation of CD36-dependent leukemia