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However, when intracellular ROS are increased, Trx is oxidized, thus leading to the dissociation of TXNIP from Trx, which subsequently interacts with NLRP3, leading to the assembly and activation of the NLRP3 inflammasome (84, 85)

Subsequently, ROS harm cells by damaging important components like DNA, lipids, and proteins, which worsens the condition of already compromised neurons

Persistent oxidative stress and Inflammasome activation in CD14 high CD16 monocytes from COVID-19 patients

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