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[PMC free article: PMC4768733] [PubMed: 26000480] 21

Wyczkowska J, Walczak-Drzewiecka A, Wagner W, Dastych J

To attain sufficient bioavailability for nasally administered proteins and peptides, absorption enhancers, including cyclodextrin, surfactants, and mucoadhesive polymers have been applied in many formulation studies ( 3.2 Pathways of transepithelial transport To reach the bloodstream on the capillaries, drugs have to pass through the mucus barrier