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Another mechanism is that a previously formed ubiquitin chain serves as a foundation for K48-linked branching, contributing to efficient K48-linked chain assembly 8,10

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The ratio of n-3 PUFA/n-6 PUFA is of the utmost importance since its disbalance may activate pro-inflammatory pathways (140) n-3 and n-6 PUFA exert opposite effects on the immune system, whereas n-3 PUFA have an anti-inflammatory effect while n-6 PUFA induces a pro-inflammatory action (141)

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