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F2-isoprostanes (F2-IsoPs) are potent vasoconstrictors ( Figure 1 There is considerable evidence that oxidative stress increases the severity of bronchial asthma ( 2 - )

Soluble vitamin C is naturally unstable and oxidises easily

The Xc- transport system which is composed of SLC3A2 and SLC7A11 proteins carries cystine into the cytoplasm where it is reduced to cysteine by thioredoxin reductases including thioredoxin reductase 1 (TXNRD1), thus participating in the synthesis of intracellular GSH, an essential cofactor for GPX4 activity

doi: 10.1073/pnas.1409638111 47 PrudhommeGJGlinkaYKurtMLiuWWangQ

Body weight was subsequently measured during the pre-partum period (three months prior to calving) and postpartum period (after calving)