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Iron is essential for mitochondrial function, but excessive iron leads to severe oxidative stress and mitochondrial dysfunction 19

In extreme cases, such as in tendons, the extracellular matrix consists almost exclusively of tightly packed, parallel bundles of collagen fibers (see Fig

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Abstract Cysteine is the precursor for the biosynthesis of glutathione, a key stress-protective metabolite, and methionine, which is imperative for cell growth and protein synthesis

However, what is likely to occur through increased nutritional research is the characterization of more and more conditionally essential nutrients and cofactors, including essential vitamins and minerals