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For uptake studies, cells were treated with Cy5-labeled paclitaxome-2, AZEpaclitaxome-2, or AZOpaclitaxome-2 (2 g ml 1 DSPECy5) for 1 h at 37 C in pH 6.5 or 7.4 medium (10% FBS)

Over the last four decades, obesity prevalence in the USA has tripled, now affecting over 42% of the population, and is associated with chronic inflammation and metabolic disturbances [25]