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Among participants receiving 36 mg, 54.6% lost at least 10% of their body weight and 36.0% lost at least 15%

The skin irritation test, performed on an in vitro reconstructed 3D human skin model, indicated that MB was safe for long-term use, and did not cause irritation even at high concentrations

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Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

This indicates that even the modelled complex contains all residues, and that the orientation of the domains/tails are not in line with the in-solution behaviour