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Lastly, the factors affecting varying alcohol sensitivity among GIRK isoforms remain unknown

They are not intended for human or veterinary use, and are not intended to diagnose, treat, cure, or prevent any disease or medical condition

[47] In addition, internalized "mega-complexes" consisting of a single GPCR, -arr(in the tail conformation), [48] [49] and heterotrimeric G protein exist and may account for protein signaling from endosomes

Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination