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A central role in the regulation and differentiation of target cells distant from the muscle is attributed to the musculature, since it secretes peptide hormones (myokines) (18)

Although the peak incidence of HG occurs between the eighth and 12th week of pregnancy, it may persist, with symptoms severe enough to require hospital admission

355,356 The abundant lipids and membrane-bound proteins on the surface of exosomes provide binding sites for targeting ligands, such as peptides, antibodies, and aptamers

The combined formulation provides a framework for studying interconnected pathways involved in tissue remodeling, cellular communication, and regenerative biochemistry relevant to mammalian models