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[7] The study revealed important cardiovascular benefits: [7] The L-citrulline + glutathione combination significantly improved flow-mediated dilation (FMD) , a measure of endothelial function and vascular health

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Following the positive REDEFINE 1 Phase 3 data (published June 2025, PMID: 40544433), Novo Nordisk announced plans to file regulatory applications for CagriSema for obesity in the United States (FDA), European Union (EMA), and other major markets in 20252026

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Chronic stress activates sympathetic nervous system responses, elevates cortisol, and creates mental hyperarousal that interferes with sleep onset and maintenancewhile poor sleep quality impairs stress resilience, reduces emotional regulation capacity, and increases vulnerability to anxiety