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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Huang Z., Rose A.H., Hoffmann P.R

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Building on these findings, Ma et al

Classical antifolate drugs, including methotrexate (targeting DHFR) [153] and fluoropyrimidine agents (targeting TYMS) [154], induce cell death in rapidly proliferating malignancies by specifically inhibiting key enzymes in 1 C metabolism, thereby depleting nucleotide pools and causing replication stress [101]

Differentially expressed genes between normal mammary tissues and TNBC tissues involved in the PI3K/Akt signaling pathway were screened based on the KEGG analysis (Fig