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Once symptoms improve, prednisone is reduced by 5-10 mg per week until the dose of 20 mg per day is reached

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From the results of the anti-proliferative studies performed, PROTAC 8 was the most potent in MM.1S (half-maximal inhibitory concentration (IC 50 ) value of 0.027 M) and MV-4-11 (IC 50 = 0.003 M) cell lines, degrading BRD4 in a time- and concentration-dependent depletion manner

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