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When released into the synaptic cleft, glutamate activates a family of ligand-gated ion channels called ionotropic receptors (named NMDA, AMPA, and KA)

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Bromelain is found in the stem and fruit of the pineapple, and previous research has explored a range of benefits, including reducing inflammation, swelling, and pain, particularly in the joints and muscles

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However, there is no evidence for this hypothesis