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Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M, et al

However, one group reported that global GRK2 knockdown impaired kidney development, and increased blood pressure [43] while another group reported that Grk2 +/ mice have normal blood pressure and attenuated response to the hypertensive effect of Ang II infusion [31]

10.1016/j.ab.2008.10.043

By coupling to many downstream intracellular cascades and effectors, the G proteins initiate pleiotropic changes in many intracellular targets

Nonetheless, because they lack certain molecular structures that strongly stimulate the immune system, they often require adjuvants or repeated booster doses to achieve durable protection [33, 34]