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The mechanisms involved in different studies are different or complicated, some of the experimental results are controversial and contradictory, and lack of systematic summary

Ashraf A, Ashton NJ, Chatterjee P et al (2020) Plasma transferrin and hemopexin are associated with altered A uptake and cognitive decline in Alzheimers disease pathology

Excessive free radicals can damage cellular components such as lipids, proteins, and DNA, contributing to chronic conditions like cardiovascular diseases, neurodegenerative disorders, cancer, and inflammatory diseases [8, 21]