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Furthermore, the metabolic pathways involved in the differential metabolites of each group were analyzed by MetaboAnalyst 5.0

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Pain occurs two or three times more frequently in patients with PD than in individuals of similar age without PD 38 , 39 , 40

AE collected articles and wrote the first draft of manuscript, JWG initiated the study and revised the manuscript and TLW finalized the manuscript

The copper ion is coordinated to the peptide through the nitrogen atoms of the glycine and histidine residues, giving the compound its distinctive blue color in crystalline form