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Nature, 543 (7608), 494-499

FSP1 is a redox enzyme that operates through its NAD(P)H-binding domain and FAD-binding domain, enabling it to exist in reduced forms, specifically CoQH2 and VKH2, from CoQ and vitamin K (VK), respectively

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At her structured 3-month follow-up visit, her CDAI score indicated she had not reached the target of low disease activity, prompting an increase in her methotrexate dosage to the maximum tolerated dose (Cohen & Mikuls, 2025