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In response to the dopaminergic neural activation induced by substances of abuse, such as heroin (119, 120), methamphetamine (121, 122), and cocaine (123), the mitochondrial respiratory chain is rapidly activated, leading to mitochondrial dysfunction, such as decreased mitochondrial membrane potential, mitochondrial DNA, and mitochondrial proteins, and increased cytochrome c release, resulting in increased ROS and oxidative stress (124)

TPL was also identified as a component of the BZR1 complex by affinity purification followed by mass spectrometry analyses 29

Cytosolic DNA-STING-NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide

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During an active flare up, corticosteroids are applied daily, but then reduced to every other day or only on weekends once in remission