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46 Molecular mechanisms of statin-induced liver injury In general, statin-induced liver injury is more likely to be seen in patients taking maximal statin doses together with other lipid lower medications, other medications that use the cytochrome P450 enzymatic pathway, and/or patients who are elderly or have severe hepatic or renal impairment

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Marchesini G., Brizi M., Bianchi G., Tomassetti S., Bugianesi E., Lenzi M., McCullough A.J., Natale S., Forlani G., Melchionda N

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In ALI-PBEC, CSE increased the IL-8 gene expression and basal and apical IL-8 release and the MIX significantly counteracted CSE effects on both IL-8 gene expression and apical and basal release (Figures 3AC) while NAC exerted counteracting activity only on IL-8 gene expression (Figure 3C)