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The method of any one of embodiments 1-68, wherein the composition further comprises a penetration enhancer

When hPSCs reached approximately 70% confluency, the culture medium was switched to RPMI1640 supplemented with 1 B27

Given the balance between the central production of BDNF and proBDNF and their circulating levels [11], the brain production of these neurotrophins can be postulated to increase during cocaine withdrawal

In some embodiments, the otoprotectant is D-methionine

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