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The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

IGFBP-3 Animal data consistently shows LR3 IGF-1 suppresses IGFBP-3 (Tomas et al., 1997

Zinc also activated mitophagy (PTEN-induced kinase 1 [PINK1], Parkin, LC3-II), and mitophagy inhibition alleviated ferroptosis, indicating a mitophagyferroptosis crosstalk mediated by HMGB1-driven redox imbalance (Wang et al., 2024c)