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Penetration Enhancement Strategies The hydrophilic nature of GHK-Cu (log P approximately -2.3) limits passive diffusion through the lipophilic stratum corneum, necessitating penetration enhancement strategies for optimal topical delivery

It may also play a role in the formation of new blood vessels, maturation of stem cells, survival of various cell types, and reducing inflammation [8, 9]

Systemic toxicity evaluationssuch as hematological parameters, biochemical profile, and organ histopathologyare also emphasized, as abnormality of these can occur via intravenous injection, a standard route of administration, for drug nanoparticles in the treatment of AD (Ma et al., 2021

1,2,3,4,5,6,7 Glutathione is also a highly important component in detoxification, allowing the physiological and pathophysiological maintenance of cell metabolism