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Genetic ablation of Hif1a inhibits Th17 cell differentiation while enhancing Treg cell lineage commitment [139]

J Extracell Vesicles 2023;12:e12299

The density of these cells positively correlates with the severity of tau pathology, and their clustered aggregation is often a harbinger of neuritic plaque formation (149, 150)

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death