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doi: 10.1007/s12602-022-09991-9 118 Lpez-MorenoA.SurezA.AvanziC.Monteoliva-SnchezM.AguileraM

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The timely removal of necrotic tissue contributes to preventing the spread of infection, which otherwise may lead to systemic infection and ultimately to multi-organ failure

This narrow focus overlooks emerging regulators [e.g., the recently identified ferroptosis suppressor protein 2 (FSP2) or the lipid kinase PI3K] and fails to account for the kidneys inherent structural and functional heterogeneity

This integrated approach leads to a significant improvement in bioenergetic capacity, which is directly translated into enhanced muscle strength and endurance