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Besides 5-HT 2 receptors, several 5-HT receptor subtypes, including 5-HT 1A , 5-HT 3 and 5-HT 6 receptors, are involved in regulation of EPS induction associated with antipsychotic treatment ( 5-HT 1A receptors function as both presynaptic autoreceptors and postsynaptic receptors, which inhibits neural activities via activating G-protein-gated inwardly rectifying K + channels ( 1A receptors is known to reduce antipsychotic-induced EPS and motor disorders in animal models of Parkinsons disease ( 1A agonists (e.g., 8-OH-DPAT) ameliorated haloperidol-induced EPS (e.g., bradykinesia and catalepsy) and reversed the striatal Fos protein expression by the haloperidol treatment ( 1A agonists persisted against the denervation of 5-HT neurons with p -chlorophenylalanine treatment, illustrating that postsynaptic 5-HT 1A receptors are responsible for EPS reduction ( 1A agonists into the striatum or the cerebral cortex (i.e., motor cortex) also attenuated extrapyramidal disorders ( 1A receptors reduces antipsychotic-induced EPS by inhibiting neural activity in the striatum and motor cortex ( Figure 5 )

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[DOI] [PubMed] [Google Scholar] Li H