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In NSCLC, specific genetic alterations in the EGFR gene, most notably exon 19 deletions and the L858R point mutation in exon 21, lead to constitutive activation of the receptor tyrosine kinase (RTK) (49,50) (Fig

Although their activity on a single target may be lower compared to single-target drugs, the synergistic effects of multi-target modulation result in a total effect greater than the sum of the individual effects, leading to better efficacy and fewer adverse reactions