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A recent meta-analysis of clinical studies to identify and assess the various diagnostic tests indicated that a combination of intestinal permeability, Rome I criteria and fecal calprotectin (see Table 1) provided the highest positive likelihood ratio for predicting IBS (Sood et al., 2015)

Orina, A., Gavrilova, O.P., Gagkaeva, T., Burkin, A., and Kononenko, G., Agr

The amount of melatonin synthesized in peripheral cells is presumed to be cell specific and stress de-pendent, i.e., potentially upregulated in animal cells as has been well documented in plants ( Figure 2 )

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