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This is called a biphasic or hormetic dose-response common in biology

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Non-Squamous NSCLC First-line Treatment of Metastatic Non-squamous NSCLC with Pembrolizumab and Platinum Chemotherapy The safety of pemetrexed, in combination with pembrolizumab and investigators choice of platinum (either carboplatin or cisplatin), was investigated in Study KEYNOTE-189, a multicenter, double-blind, randomized (2:1), active-controlled trial in patients with previously untreated, metastatic non-squamous NSCLC with no EGFR or ALK genomic tumor aberrations

The peptide stimulates production of VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor), both critical for building new capillary networks

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