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The hydroxyl moiety combines with the peroxyl radical (ROO ) via a coordinated pathway from the phenol to the radical, resulting in a transition state with an H-O bond containing one electron [204]

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The molecular mechanism may be achieved by inhibiting the ubiquitination of TNF receptor associated factor 6 (TRAF6), the aggregation of TRAF6-TAK1 complex and the activation of MAPKs/NF-B/c-Fos/nuclear factor of activated T cell cytoplasmic 1 (NFATc1) pathway to prevent the differentiation and function of osteoclasts

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