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These ROS are primarily generated through the enzymatic activity of monoamine oxidase (MAO) and other enzymes involved in DA metabolism

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Mast Cell Flares (Hives, Flushing, GI Distress): By acting as a potent antioxidant, glutathione neutralizes the reactive oxygen species that provoke mast cells into degranulating, helping to stabilize the release of histamine and inflammatory cytokines

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