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Genetics and Epigenetics of Manganese Toxicity

10.9734/JAMPS/2016/24196 37 DurazzoA.LucariniM.NazhandA.ColhoA

Because physical exercise increases the demand on the weakened heart, measures of exercise tolerance are frequently used to monitor the severity of heart failure

These findings suggest that the decline in endogenous melatonin levels with age may contribute to the onset or severity of age-related neurodegenerative disorders

Specifically, shorter PBMC TL may be associated with smaller hippocampal volumes 74,75 which has been related to treatment resistance in animal models 76 as well as human studies 77