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Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

Dobutamine is a synthetic, direct-acting catecholamine that primarily stimulates -adrenergic receptors to enhance myocardial contractility and increase cardiac output

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Mechanistically, gallic acid and its esters combat the oxidative and inflammatory damage in PD through several pathways

Boxplots showing the concentrations (y-axis) of the significantly altered metabolites in control (n = 9), compared to 50 (n = 9), 35x6 (n = 9), and 4+1 (n = 9) treatment groups analyzed by one-way ANOVA, p-value 0.1)