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Moreover, chronic increases in plasma 5-HT levels also lead to a reduction in SERT expression, further decreasing its uptake by platelets [281]

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Anemia is an important cause of chemotherapy-induced fatigue, and treating chemotherapy-induced anemia may prevent or improve fatigue (Mahoney 2014)

J Enzyme Inhib Med Chem 2015;30:87483

Compared with the PA-control cells, PGC-1 over-expression decreased lipid and iron accumulation, Drp1, Drp1 phosphorylation, ACSL4 and TFR1 expression, partially restored PGC-1, Tim23, GPX4 and FTH1 expression and GSH levels in the PA-treated hepatocytes (Fig