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Moreover, a recent study associates PD with the hypermethylation and consequent downregulation in blood cells of SLC7A11 , the gene coding for the System xc- cystine/glutamate antiporter

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42, 43, 44 In addition, knockout mice that lack a crucial subunit of the GCL enzyme show significant reduction of glutathione levels in the anterior cortex, 45 especially during the prepuberal period, which is followed by SZ-like behaviour in the time frame of disease onset 46 and SZ-like neural changes in the hippocampus (HIP) of the adult knockout mice, including an increase in oxidative stress and a decrease in the number of parvalbumin (PV) interneurons

However, non-genetic resistance mechanisms are also crucial, particularly the formation of drug-tolerant persister (DTP) cells (13, 15, 16)

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