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Supplemental vitamin B12 may improve the efficacy of antidepressants, according to certain studies

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Three weeks of six days per week high intensity resistance training increased oxidative stress in blood as indicated by serum thiobarbituric acid-reacting substances (TBARS), which is an indicator of lipid peroxidation, by 56% while reducing whole blood total glutathione content (GSH) by 31% (an endogenous antioxidant), and total antioxidant capacity (TAC) by 20% [11]

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[1] [2] The vitamin's water-soluble nature means that excess amounts are typically excreted through urine rather than accumulating in the body to toxic levels