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In humans, NAC and GSH supplementation has demonstrated its efficacy in several pathologies, and the most interesting results have been obtained in cardiovascular, pulmonary and viral diseases

Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways

However, further evidence is needed to confirm whether -agonists might act directly on immune cells and are thus capable of modulating PD-related inflammation (122)

Regulation and removal of hydrogen peroxide prevents the formation of the highly reactive and damaging hydroxyl radical, which can be formed by reaction of hydrogen peroxide with Fe 2+ (Fenton reaction)