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Identification of the same variant in family 6, who present with a similar and consistent phenotype, and reanalysis using the ACMG guidelines has deemed this variant likely pathogenic (Table 2)

Monitoring Side Effects Prior to starting thiopurine therapy, a clinical assessment should be performed to ascertain whether patients are at risk of developing opportunistic infection or adverse drug reactions

Cross-talk between phytohormone signaling pathways under both optimal and stressful environmental conditions

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