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Description

They are crucial for the survival and function of plasma cells, which anti-CD20 antibodies cannot eliminate due to the lack of surface CD20 [97]

Blackman MR, Sorkin JD, Munzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, OConnor KG, Christmas C, Tobin JD, Stewart JK, Cottrell E, St Clair C, Pabst KM, Harman SM

Boul et al., 2021)

J., Dick, G

ERK5 is a known weak client of Hsp90, and prolonged occupancy of the N-terminal ATP-binding pocket by potent inhibitors such as ganetespib or by HLX itself destabilizes a subset of Hsp90 clients, including ERK5 [48,49,50]