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Preclinical rodent studies did not report significant adverse events at tested doses, but animal toxicity data does not reliably predict human safety, and the absence of long-term studies means chronic effects remain uncharacterized

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For example, Norbert Fuchs argues that homocysteine is not itself the cause of diseases, but only the indicator of a nutrient deficiency

It is a synthetic peptide corresponding to a sequence within the N-terminal region of SNAP-25 (amino acids 12-17) and competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation