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As a key transcription factor in the antioxidant response, NRF2 upregulates GPX4 expression by binding to the antioxidant response element (ARE) in the promoter region of the GPX4 gene [96]

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The influence of exposure to inorganic arsenic and other arsenic species on early renal impairment among young adults in Taiwan

This includes three steps ( Figure S1A ): 62 definition of the extra-parasitic environment in the metabolic model, (2) identification of the minimal number of reactions required for growth, the resulting set of reactions is called minimal network (MiN), and (3) generation of an individual reaction by collapsing all the reactions present in the MiN into one lumped reaction