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ASK1, apoptosis-regulated signaling kinase 1

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Dysfunction of these cells contributes to chronic inflammatory and autoimmune diseases such as gout, rheumatoid arthritis (RA), osteoarthritis (OA), cryopyrin-associated periodic syndromes (CAPS), inflammatory bowel disease, and neurodegeneration

Additionally, a profound decline in FBS, insulin, and HOMA-IR ( p = 0.014, 0.051, 0.024, respectively) and an increment in QUICKI ( p = 0.019) were observed in the L-carnitine + synbiotic group compared with the L-carnitine + placebo group post-intervention, which remained significant after adjustment for the baseline levels and possible confounding factors

UC = U.S.-Canadian Study