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Elevated GH even pituitary-derived GH stimulated by secretagogues can worsen insulin sensitivity transiently, particularly in the first 48 weeks of therapy.9 Adults with existing insulin resistance or prediabetes require close glucose monitoring

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Overcoming apoptosis defect-induced resistance GBM is a common primary malignant brain tumor in adults, and TMZ is the only chemotherapeutic drug with clear efficacy against GBM

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