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We hypothesize, based on the current evidence, that the reduced activity of MTHFR could exert its effect on the development of these diseases by both reduced metabolism of folate and increased buildup of circulating Hcy 49

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Only after the quantification, we un-blinded the samples to allocate them to the respective groups)

Mitochondrial dysfunction, elevated cholesterol levels (hyperlipidemia), metabolic syndrome, and other metabolic disorders are also more common in hypothyroidism, and these conditions can increase oxidative stress

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