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Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis

RowlandIGibsonGHeinkenAScottKSwannJThieleIet al

Experiments conducted on isolated bovine chondrocytes also revealed an apparent upregulation in the production of proteoglycans and collagen in these laboratory settings, fundamental components of the extracellular matrix considered essential for cartilage integrity

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Without human PK/PD, there is no established relationship between an administered amount and a plasma concentration, no half-life, no tissue-distribution data, and therefore no rational basis for any human dosing