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2.7 Model Evaluation and Model Selection Model development and model selection were guided by comparison of the objective function value between nested models, model stability and precision of parameter estimates

These include: Sodium, potassium and urea (alternate days if on IV fluids) LFTs, glucose (weekly) TFTs and calcium if vomiting is persistent FBC to exclude infection Daily urinalysis to monitor change in ketotic state MSU Pelvic ultrasound to assess for multiple birth and exclude a hydatidiform mole or other gynaecological pathology causing vomiting and abdominal pain, for example, ovarian cyst Section 3: Managing the condition The mainstay of treatment is to correct hypovolaemia and prevent complications

Changes can be gradual, and paying attention to patterns over time offers clarity and confidence

VIP also regulates the activity of immune cells, such as T cells and macrophages, promoting a more controlled immune response

Randomized clinical trial of how long-term glutathione supplementation offers protection from oxidative damage and improves hba1c in elderly type 2 diabetic patients