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J ImmunoTherapy Cancer (2021) 9(1):e001643

Recording of the APEX2 Soret peak (absorbance at 406 nm) from a mixture of APEX2 (5 M) and H 2 O 2 (10 M), to which GSH (1 mM) and Na 2 S 4 (10 M) were added (right panel)

PloS One 6, e24479

It appears, therefore, that maintenance of glutathione equilibrium (and by inference, the shuttling between reduction and oxidation states) is a prerequisite for HIF-1 stabilization [82, 109]